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The Genital Warts &
Herpes Treatment

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Medical Studies

Oxygenated therapies, such as that used in our genital warts treatment have been the subject of numerous medical studies and there exists plenty of medical opinion to support their efficacy at treating a wide range of conditions. Here we provide just a few examples of medical experts' opinions upon the application of bio-oxidative medication.


Genital Warts and Herpes - Bio-oxidative Treatment

Considered one of the leading authorities on medical ozone (the active ingredient in our product.), Dr. Shallenberger has done a summary of the thirteen physiological effects of medical ozone.

According to F. Shallenberger, M.D Bio-oxidatives (such as the saturated oxygen in our cream) are successful at fighting disease because (1):



   “1. Ozone stimulates the production of white blood cells. These cells protect the body from viruses, bacteria, fungi and cancer. Deprived of oxygen, these cells malfunction. They fail to eliminate invaders and even turn against normal, healthy cells (allergic reactions). Ozone significantly raises the oxygen levels in the blood for long periods after ozone administration; as a result, allergies have a tendency to become desensitized. 

    2. Interferon levels are significantly increased. Interferons are globular proteins. Interferons orchestrate every aspect of the immune system. Some interferons are produced by cells infected by viruses. These interferons warn adjacent, healthy cells of the likelihood of infection; in turn, they are rendered nonpermissive host cells. In other words, they inhibit viral replication. Other interferons are produced in the muscles, connective tissue and by white blood cells. Levels of gamma interferon can be elevated 400-900% by ozone. This interferon is involved in the control of phagocytic cells that engulf and kill pathogens and abnormal cells. Interferons are FDA approved for the treatment of Chronic Hepatitis B and C, Genital Warts (caused by Papillomavirus, Hairy-cell Leukemia, Karposi’s Sarcoma, Relapsing-Remitting Multiple Sclerosis and Chronic Granulomatous Disease. Interferons are currently in clinical trials for Throat Warts (caused by Papillomavirus), HIV infection, Chronic Myelogenous Leukemia Leukemia, Non-Hodgkins Lymphoma, Colon tumors, Kidney tumors, Bladder Cancer, Malignant Melanoma, Basal Cell Carcinoma and Leishmaniasis. While levels induced by ozone remain safe, interferon levels that are FDA appoved (and in clinical trials) are extremely toxic. 

    3. Ozone stimulates the production of Tumor Necrosis Factor. TNF is produced by the body when a tumor is growing. The greater the mass of the tumor the more tumor necrosis factor is produced (up to a point). When a tumor has turned metastatic, cancer cells are breaking off and being carried away by the blood and lymph. This allows the tumor to take up residence elsewhere in the body; or in other words, divide its forces. These lone cancer cells have little chance of growing due to the TNF produced to inhibit the original tumor. When the tumor is removed surgically TNF levels drop dramatically and new tumors emerge from seemingly healthy tissue. 

    4. Ozone stimulates the secretion of IL-2. Interluekin-2 is one of the cornerstones of the immune system. It is secreted by T-helpers. In a process known as autostimulation, the IL-2 then binds to a receptor on the T-helper and causes it to produce more IL-2. Its main duty is to induce lymphocytes to differentiate and proliferate, yielding more T-helpers, T-suppressors, cytotoxic T’s, T-delayed’s and T-memory cells. 

    5. Ozone kills most bacteria at low concentrations. The metabolism of most bacteria is on average one-seventeenth as efficient as our own. Because of this, most cannot afford to produce disposable anti-oxidant enzymes such as catalase. Very few types of bacteria can live in an environment composed of more than two percent ozone. 

    6. Ozone is effective against all types of fungi. This includes systemic Candida albicans, athletes foot, molds, mildews, yeasts and even mushrooms. 

    7. Ozone fights viruses in a variety of ways. As discussed above, ozone also goes after the viral particles directly. The part of the virus most sensitive to oxidation is the “reproductive structure”. This is how the virions enter the cell. With this structure inactivated, the virus is essentially “dead”. Cells already infected have a natural weakness to ozone. Due to the metabolic burden of the infection the cells can no longer produce the enzymes necessary to deal with the ozone and repair the cell. 

   
8.  The direct application of the ozone to the wound eliminates all bacteria, viruses, and fungi, sterilizes the necrotic tissue, helps regenerate healthy tissue, enhances blood circulation, and promotes wound closure and recovery at over 200% of the normal rate.

    9. Ozone oxidizes arterial plaque. It breaks down the nnnn plaque involved in both Arteriosclerosis and Arthrosclerosis. This means ozone has a tendency to clear blockages of large and even smaller vessels. This allows for better tissue oxygenation in deficient organs. 

    10. Ozone increases the flexibility and elasticity of red blood cells. When one views a red blood cell under a microscope, it looks like a disc. In the capillaries, where they pick-up (lungs) and release (tissue) oxygen, these discs stretch out into the shape of an oval or umbrella. This aids their passage through the tiny vessels and makes the exchange of gas more efficient. The increase in flexibility of the RBC’s allows oxygen levels to stay elevated for days, even weeks after treatment with ozone. 

    11. Ozone accelerates the Citric Acid Cycle. Also known as the Kreb’s Cycle or TCA Cycle, this is a very important step in the glycolisis of carbohydrate for energy. This takes place in the mitochonria of the cell. Most of the energy stored in glucose (sugar) is converted in this pathway. 

    12. Ozone makes the anti-oxidant enzyme system more efficient. 

    13. Ozone degrades petrochemicals. These chemicals have a potential to place a great burden on the immune system. They also worsen and even cause allergies and are detrimental to your long-term health.”




Genital Warts - H2O2 Treatment


The bio-oxidative present in our genital warts and herpes treatment is H202. F. S. and Archibald M.N. Duong have the following to say about H2O2 in the treatment of disease:


All of life's vital processes depend upon the presence of H2O2, and H2O2 is required in order for the immune system to defend the body against pathogens. The white blood cells in the body that fight infection (known as granulocytes) produce H2O2 as a first line of defense against invading organisms like parasites, viruses, bacteria and yeast. Some of the biological killing activity of H202 can be attributed to gamma interferon (IFNs). The production of gamma interferon by human natural killer cells and monocytes, is stimulated by the presence of H202 (2).

T. Ramasarma, writing about the effectiveness of H2O2 treatment, observes that:


H2O2 has long been used medically as an antiseptic, disinfectant and oxidizer, but has only recently been found to successfully treat a wide variety of human diseases with a minimum of negative side effects

H2O2 appears to be involved in many intermediate biochemical pathways. Additionally, it appears to kill certain bacteria, parasites, yeast, protozoa, inhibit viruses, and oxidize immunocomplexes. (3)


  1. Frank, "Intravenous Ozone Therapy in HIV-related Disease" Proceedings: Fourth International Bio-Oxidative Medicine Conference, April 1993.
  2. Archibald FS and Duong MN: Superoxide Dismutase and Oxygen Toxicity Defenses in the Genus Neisseria. Infect Immun 1986; 51(2): 631-41
  3. Mallams JT, Finney JW, and Balla GA: The Use of Hydrogen Peroxide As A Source of Oxygen in A Regional Intra-Arterial Infusion System. So M J 1962; 55: 230-232

Ozone as a Therapy in Herpes Simplex (Shingles) and Herpes Zoster Diseases.


AU: Mattassi, R.M.D., D'Angelo F.,M.D., Franchina A.,M.D., Bassi P.,M.D.

SO: From the Division of Vascular Surgery, Santa Corona Hospital, Milan, Italy


Abstract

It is known from many researches that ozone has a high antibacterial and antiviral effect and this is utilized in the industrial treatment of drinking water. Authors of this paper tried to utilize this ozone effect in the treatment of some viral diseases of man. 30 patients with herpes zoster (shingles) and 27 with herpes simplex were treated with applications of an oxygen-ozone mixture. Patients with herpes zoster healed from cutaneous lesions after a minimum of five and a maximum of 12 applications. 5 elderly patients complained of postherpetic pain. Herpes simplex healed completely after a minimum of 1 and a maximum of 5 application. Only 3 recurrence of herpes were observed in 3 years. No side effects were noticed during treatment in all patients. 

Herpes virus is a group of DNA-virus that range in size between 120 and 180 nm; they contain a lipid envelope, are sensible to ether and have a cubic symmetry. Virus multiplication is intracellular. After entering the cell by pinocytosis, nucleic acid is stripped from the capsid and specific virus DNA strands are transcribed into specific mRNA, which is, in turn, translated to synthesize virus-specific proteins and enzymes necessary for biosynthesis of virus DNA. Newly formatted complete virions may be released by cell lysis of budding from the cytoplasm (1). Principal routes of infection in man may be respiratory, direct contact, transplacentar (H. Hominis), breast milk and feces (Cytomegalovirus). 

The main diseases occurring in man from these agents are:

  • Varicella (chickenpox)
  • Herpes Zoster
  • Herpes Simplex
  • Herpes labialis
  • Herpes genitalis
  • H. Hominis Type 1 and Type 2
  • Acute gingivostomatitis
  • Rhinitis
  • Keratoconjunctivitis
  • Meningoencephalitis
  • Eczema herpeticum
  • Cytomegalic inclusion disease

Herpes zoster is a disease caused by the same virus as varicella. It has been suggested that it results from reactivation of virus that has lain dormant in spinal nerves since an episode of chickenpox (2). It occurs often in patients with neoplasm, specially lymphomas (3) and in elderly patients. It is characterized by unilateral segmental inflammation of the spinal or cranial nerves and their ganglions and by a painful localized vesicular eruption of the skin along the distribution of the involved nerve. Skin lesions starts with local redness and progress over the next 2 - 3 weeks through red papules, vesicules, pustules and crusts. In young people pain persists only a week or two after healing but in elderly patients it often remains for over two months. 

Herpes simplex is a chronic local infection of Herpes virus Hominis type I with clinical recurrences associated with continued virus shedding rather than reactivation of latent infection (4). Often recurrence appears after infective diseases, exposure to sunlight, menstruations and tiredness. Typically the disease is preceded by a brief period of itching and inflammation followed by a vesicular eruption that later collapses and ulcerates leaving a crust. The disease lasts about 8 - 15 days. Local iodoxuridine can shorten pain and morbidity somewhat. No therapy is available to prevent recurrence. 

In spite of this excellent antiviral and antibacterial effect, ozone has not been widely utilized in medicine because of the widespread belief that it is toxic to man (13, 14). This opinion varies widely from the fact that researches about ozone effects on animals were done by only observing respiratory tract lesions after long-term inhalation of ozone. In fact, while it is true that ozone is toxic if inhaled (but it is only a local toxicity), it is also true that given in forms other than inhalation (endovenous, intraarterial, intramuscular, subcutaneous, local, transdermal) there is no toxic effect (15,16,17).

To investigate the effect of ozone on some viral diseases we treated a group of patients affected by Herpes Zoster and Herpes Simplex

Material and Methods

In the period 1980-1982 we treated 30 patients affected by Herpes Zoster and 27 affected by Herpes simplex. In the Herpes Zoster group 13 were men and 17 women. Age range was from 9 to 76 years and the mean age was 41.4. In the Herpes simplex group, 12 were men and 15 women. Age range was from 15 to 53 and the mean age was 34.5. 

  • Face 5 cases
  • Neck 2 cases
  • Thorax 12 cases
  • Abdomen 8 cases
  • Upper limbs 1 case
  • Lower limbs 2 cases

Total 30 cases

Therapy performed in all patients consisted of applications of 20cc of a oxygen-ozone mixture. The concentration of ozone was 20 gamma of ozone per cc (20 ug/ml) of oxygen-ozone mixture. Applications were performed  twice daily and were stopped at complete healing (except in 5 patients of the Herpes Zoster group and in 3 of the Herpes Simplex group which broke up therapy before ending; see below).

Results

Herpes Zoster: in all patients healing of skin lesions were observed after a minimum of 5 and a maximum of 12 ozone applications. In the greater part of patients (21) we had a disappearance of local redness after only 2-3 days of therapy: especially in those patients that started therapy quickly at the beginning of symptoms (fig. I and 2). Contemporaneously vesicules dried up and crusts appeared. After beginning therapy no new vesicules appeared. The disease course was "cut off" and complete healing was very quick. 5 patients broke up therapy because they felt well after a few applications; 2-4 days later new vesicules and pain appeared. Complete healing was achieved after another cycle of therapy. Usually pain regressed contemporaneously with disappearance of local redness; itching persisted for some days while going on with therapy but disappeared at the end of therapy. In the other 5 patients, skin lesions healed but neuritis post-herpetica lasted for over 2 months; all of these patients were elderly (over 70 years) and started therapy late after the beginning of symptoms. The other patients never had neuritis post-herpetica. 

Herpes Simplex: all patients healed after 1-5 applications. Best results were reached in patients that began therapy early before vesicules appeared; in these cases the disease healed directly without the appearance of vesicules in 1-2 days. 3 patients with severe herpes simplex stopped therapy after only one application and observed appearance of new vesicules; a new cycle of treatment allowed complete healing. It was noticed that other patients with slight herpes healed after only one application. Very interesting that of this group of 27 patients treated, only 3 complained a recurrence of disease and this recurrence were clearly attenuated in comparison with their usual disease. The other 24 patients had no recurrence during period of control (maximum 3 years). 

According to these results we can assert that ozone seemed to be very effective in the therapy of herpes zoster and herpes simplex diseases. We observed a clear shortening of the course of disease and, if therapy starts early, also a "cut-off" of the course of disease. It can be possible also that ozone obtains a complete healing of herpes simplex without recurrence after therapy but it is necessary to have a longer time of control. It was important to perform applications twice daily, to continue therapy till healing was complete and not to stop treatment prematurely because immediate recurrence of the disease is possible. It is interesting to notice the absence of side effects with ozone applications. 




 
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